Arhgef1 Deletion Reduces Agonist\Induced Integrin IIb3 Activation Activation of integrin GPIIb\IIIa (IIb3) is required for platelet aggregation49 and involves conformational changes of the latter upon agonist activation.50 Since aggregation was defective in the Arhgef1 deletion platelets, we investigated whether there is a commensurate defect in integrin IIb3 activation. demonstrate, for the first time, that Arhgef1 … Continue reading Arhgef1 Deletion Reduces Agonist\Induced Integrin IIb3 Activation Activation of integrin GPIIb\IIIa (IIb3) is required for platelet aggregation49 and involves conformational changes of the latter upon agonist activation